Environmental/Chemical Pathogenesis

 

Directors: Lauren Aleksunes, PhD; Jeffrey Laskin, PhD; and Jason Richardson, PhD
Members:
William Belden, PhD; Suzie Chen, PhD; Emanuel DiCicco-Bloom, PhD; Donald Gerecke, PhD; Lawrence Golbe, PhD; Marion Gordon, PhD; Andrew Gow, PhD; Grace Guo, PhD; Muhammed Hossain, DVM, PhD; Ah-Ng (Tony) Kong, PhD ; Debra Laskin, PhD; JK Lee, PhD; Kiran Madura, PhD; Kenneth Reuhl, PhD; Jason Richardson, PhD; Troy Roepke, PhD; Dipak Sarkar, PhD; Jay Tischfield, PhD; Mehmet Uzumcu, PhD; George Wagner, PhD; William Welsh, PhD; Lori A. White, PhD; CS Yang, PhD; Guofeng You, PhD; Helmut Zarbl, PhD; Liping Zhao, PhD; Renping Zhou, PhD

CEED is recognized for its mechanistic studies defining the role of environmental exposures in disease pathogenesis. The Core works closely with other Research Cores to incorporate biological response indicators or biomarkers into clinical and population studies to mitigate exposures and disease. By engaging the Community Outreach and Education Core, this Core is able to translate findings to vulnerable populations, diseased cohorts, and interested stakeholders. Using model systems, human studies, and emerging science and technologies to identify vulnerable populations and developmental stages, they study uptake and metabolism as a function of genetic and epigenetic background and life stage, and develops biological response indicators that link exposures to disease.

The Core has four mechanistic themes that cut across disease endpoints:
  1. Influence of age and development on toxicity
  2. Transport and metabolism of toxicants
  3. Cellular injury; inflammation, and repair
  4. Epigenetic and genetic mechanisms in toxicity and pathogenesis

Pthalate-induced inflammation in neonatal intensive care

Pthalate-induced inflammation in neonatal intensive care

Epigenetic modulation of circadian rhythym by carcinogens and chemopreventive agents (modified from figure in J Biol Chem 2009 284: 20408-17)

Epigenetic modulation of circadian rhythym by carcinogens and chemopreventive agents
(modified from figure in J Biol Chem 2009 284: 20408-17)