Population Exposures and Outcomes Core
Population Exposures and Outcomes
The Population Exposures and Outcomes core unites researchers who study human health using a range of approaches from controlled clinical experiments to community-engaged research. Monthly meetings facilitate collaborations and foster capacity for exchange of ideas across the translational continuum.
Core Directors
Maternal-Child Environmental Health
The Maternal-Child Environmental Health Lab examines the impact of environmental chemicals and psychosocial stressors on pregnancy and child development. We focus on pregnancy because exposures during early life (including gestation) can have profound and long-lasting impacts on health and development across the lifespan. Much of our work focuses on endocrine disrupting chemicals that interfere with the typical hormone environment during pregnancy, such as phthalates, per- and polyfluoroalkyl substances, and mycoestrogens. Through our ongoing pregnancy cohort studies, we hope to improve our understanding of how these widespread exposures affect our bodies and ultimately, improve maternal and child health.
Understanding Pregnancy Signals and Infant Development is an ongoing prospective birth cohort designed to study maternal prenatal psychological distress and child health. UPSIDE’s key design elements including (1) serial maternal questionnaire and biomarker data across all trimester and (2) pediatric visits at seven time points from birth to 4 years old, allow researchers to examine multiple exposures impacting maternal and child health.
The Infant Development and the Environment Study is a multi-center study designed to examine how everyday chemicals in food, cosmetics, and household products may affect children’s health and development. TIDES researchers are particularly interested in how the mother’s exposure to these chemicals while pregnant may affect children before they are born with changes observable during childhood and later.
The ECHO Program is an extramurally funded program maintained within the Office of the Director at the National Institutes of Health (NIH). The program aims to determine what factors give children the highest probability of achieving the best health outcomes over their lifetimes. ECHO enrolled children from previously establish cohorts and follow them over multiple life stages to understand the etiology of maternal health outcomes such as premature birth, obesity, autism, asthma and behavioral assets that strength resiliency and improve outcomes. Both UPSIDE and TIDES participate in the ECHO program. Our investigators have additional ECHO projects and participate in ECHO writing groups
Select Recent Core Publications
Barrett ES, Rivera-Núñez Z, Getz K, Ohman-Strickland P, Zhang R, Kozlosky D, Doherty CL, Buckley BT, Brunner J, Miller RK, O’Connor TG, Aleksunes LM. Protective role of the placental efflux transporter BCRP/ABCG2 in the relationship between prenatal cadmium exposure, placenta weight, and size at birth. Environ Res. 2023 May 15;225:115597. doi: 10.1016/j.envres.2023.115597. Epub 2023 Mar 1. PMID: 36863650; PMCID: PMC10091184.
Rivera-Núñez Z, Jimenez ME, Crabtree BF, Hill D, Pellerano MB, Devance D, Macenat M, Lima D, Gordon M, Sullivan B, Rosati RJ, Ferrante JM, Barrett ES, Blaser MJ, Panettieri RA Jr, Hudson SV. Experiences of Black and Latinx health care workers in support roles during the COVID-19 pandemic: A qualitative study. PLoS One. 2022 Jan 18;17(1):e0262606. doi: 10.1371/journal.pone.0262606. PMID: 35041702; PMCID: PMC8765643.
Rivera-Núñez Z, Kinkade CW, Khoury L, Brunner J, Murphy H, Wang C, Kannan K, Miller RK, O’Connor TG, Barrett ES. Prenatal perfluoroalkyl substances exposure and maternal sex steroid hormones across pregnancy. Environ Res. 2023 Mar 1;220:115233. doi: 10.1016/j.envres.2023.115233. Epub 2023 Jan 5. PMID: 36621543; PMCID: PMC9977559.
Graber JM, Black TM, Shah NN, Caban-Martinez AJ, Lu SE, Brancard T, Yu CH, Turyk ME, Black K, Steinberg MB, Fan Z, Burgess JL. Prevalence and Predictors of Per- and Polyfluoroalkyl Substances (PFAS) Serum Levels among Members of a Suburban US Volunteer Fire Department. Int J Environ Res Public Health. 2021 Apr 2;18(7):3730. doi: 10.3390/ijerph18073730. PMID: 33918459; PMCID: PMC8038206.
Myers NT, Laumbach RJ, Black KG, Ohman-Strickland P, Alimokhtari S, Legard A, De Resende A, Calderón L, Lu FT, Mainelis G, Kipen HM. Portable air cleaners and residential exposure to SARS-CoV-2 aerosols: A real-world study. Indoor Air. 2022 Apr;32(4):e13029. doi: 10.1111/ina.13029. PMID: 35481935; PMCID: PMC9111720.
Sittiwang S, Nimmapirat P, Suttiwan P, Promduang W, Chaikittipornlert N, Wouldes T, Prapamontol T, Naksen W, Promkam N, Pingwong S, Breckheimer A, Cadorett V, Panuwet P, Barr DB, Baumert BO, Ohman-Strickland P, Fiedler N. The relationship between prenatal exposure to organophosphate insecticides and neurodevelopmental integrity of infants at 5-weeks of age. Front Epidemiol. 2022;2:1039922. doi: 10.3389/fepid.2022.1039922. Epub 2022 Dec 14. PMID: 36925965; PMCID: PMC10016628.
Iyer HS, Vaselkiv JB, Stopsack KH, Roscoe CJ, DeVille NV, Zhang Y, Penney KL, Balk SP, Fiorentino M, Hart JE, James P, De Vivo I, Mucci LA, Laden F, Rebbeck TR. Influence of neighborhood social and natural environment on prostate tumor histology in a cohort of male health professionals. Am J Epidemiol. 2023 May 3:kwad112. doi: 10.1093/aje/kwad112. Epub ahead of print. PMID: 37139568.
Stratton SA, Ettinger AS, Doherty CL, Buckley BT. The lead and copper rule: Limitations and lessons learned from Newark, New Jersey. WIREs Water. 2023 Jan-Feb;10(1):e1620. doi: 10.1002/wat2.1620. Epub 2022 Oct 11. PMID: 37032806; PMCID: PMC10077897.
Contact
Emily Barrett: Emily.Barrett@eohsi.rutgers.edu
Zorimar Rivera-Nunez: Zorimar.Nunez@eohsi.rutgers.edu
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