Population Exposures and Outcomes Core

Population Exposures and Outcomes Research Core

The core supports the mentorship of early career trainees including multiple doctoral students and early career faculty who have been awarded NIEHS F31 fellowships K awards. Population Exposures and Outcomes Research Core meetings provide opportunities for these rising stars to receive early stage, constructive feedback on their research. The Population Exposures and Outcomes Research Core works closely with the Pathogenesis of Environmental Disease Research Core [hyperlink to other Core] in order to translate their findings from humans to causal mechanisms in model systems.

Core Directors

Core Focus

The core supports the mentorship of early career trainees including multiple doctoral students and early career faculty who have been awarded NIEHS F31 fellowships K awards. Population Exposures and Outcomes Research Core meetings provide opportunities for these rising stars to receive early stage, constructive feedback on their research. The Population Exposures and Outcomes Research Core works closely with the Pathogenesis of Environmental Disease Research Core in order to translate their findings from humans to causal mechanisms in model systems.

Community-Engaged Research

Many projects in this core directly address priorities in our local communities, with some projects co-designed or co-led by community partners. Recent research in the core has addressed community concerns around forever chemicals, lead, and air pollution across NJ, prioritizing “research that matters” to the communities CEED serves.

Special Populations

Recognizing that environmental exposures are not distributed evenly populations and may affect people differently, research in this core often focuses on special populations that may be particularly vulnerable because of their life stage (e.g., pregnant women, children, the elderly) or occupation (e.g., firefighters, military personnel, landscapers).

Characterizing Individual and Population Exposures

Working closely with the Chemical Analysis
and Detection core, Population Exposures and Outcomes Research Core members characterize exposures to chemical contaminants (e.g. metals, plasticizers, flame retardants, forever chemicals) in human biospecimens from prospective cohort studies. Core members additionally leverage big data from electronic medical records, claims data, geospatial resources and more to model individual- and population-level exposures using machine learning and other cutting edge approaches.

Maternal-Child Environmental Health

Understanding Pregnancy Signals and Infant Development is an ongoing prospective birth cohort designed to study maternal prenatal psychological distress and child health. UPSIDE’s key design elements including (1) serial maternal questionnaire and biomarker data across all trimester and (2) pediatric visits at seven time points from birth to 4 years old, allow researchers to examine multiple exposures impacting maternal and child health.

The Infant Development and the Environment Study is a multi-center study designed to examine how everyday chemicals in food, cosmetics, and household products may affect children’s health and development. TIDES researchers are particularly interested in how the mother’s exposure to these chemicals while pregnant may affect children before they are born with changes observable during childhood and later.

The ECHO Program is an extramurally funded program maintained within the Office of the Director at the National Institutes of Health (NIH). The program aims to determine what factors give children the highest probability of achieving the best health outcomes over their lifetimes. ECHO enrolled children from previously establish cohorts and follow them over multiple life stages to understand the etiology of maternal health outcomes such as premature birth, obesity, autism, asthma and behavioral assets that strength resiliency and improve outcomes. Both UPSIDE and TIDES participate in the ECHO program. Our investigators have additional ECHO projects and participate in ECHO writing groups

The Maternal-Child Environmental Health Lab examines the impact of environmental chemicals and psychosocial stressors on pregnancy and child development. We focus on pregnancy because exposures during early life (including gestation) can have profound and long-lasting impacts on health and development across the lifespan.  Much of our work focuses on endocrine disrupting chemicals that interfere with the typical hormone environment during pregnancy, such as phthalates, per- and polyfluoroalkyl substances, and mycoestrogens. Through our ongoing pregnancy cohort studies, we hope to improve our understanding of how these widespread exposures affect our bodies and ultimately, improve maternal and child health.

Recent Core Publications

Rivera-Núñez Z, Kinkade C, Brinker A, Zhang R, Buckley B, Brunner J, Ohman-Strickland P, Qiu X, Qasem RJ, Fallon JK, Smith PC, Miller RK, Salafia CS, O’Connor TG, Aleksunes LM, Barrett ES. Mycoestrogen Exposure during Pregnancy: Impact of the ABCG2 Q141K Variant on Birth and Placental Outcomes. Environ Health Perspect. 2025 May;133(5):57001. doi: 10.1289/EHP14478. Epub 2025 May 5. PMID: 40126888; PMCID: PMC12052082.

Cedeño Laurent JG, Parhizkar H, Calderon L, Lizonova D, Tsiodra I, Mihalopoulos N, Kavouras I, Alam M, Baalousha M, Bazina L, Kelesidis GA, Demokritou P. Physicochemical Characterization of the Particulate Matter in New Jersey/New York City Area, Resulting from the Canadian Quebec Wildfires in June 2023. Environ Sci Technol. 2024 Aug 20;58(33):14753-14763. doi: 10.1021/acs.est.4c02016. Epub 2024 Jul 10. PMID: 38984996; PMCID: PMC12129129.

Barrett ES, Wadie K, Getz K, Greenberg P, Moore T, Llanos AAM. Evaluating personal care product use by Environmental Working Group hazard scores in relation to consumers’ sociodemographic characteristics, purchasing behaviors, and product safety perceptions. J Expo Sci Environ Epidemiol. 2025 Feb 21. doi: 10.1038/s41370-025-00751-9. Epub ahead of print. PMID: 39979547.

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