The Population Exposures and Outcomes core unites researchers who study human health using a range of approaches from controlled clinical experiments to community-engaged research. Monthly meetings facilitate collaborations and foster capacity for exchange of ideas across the translational continuum.
The Maternal-Child Environmental Health Lab examines the impact of environmental chemicals and psychosocial stressors on pregnancy and child development. We focus on pregnancy because exposures during early life (including gestation) can have profound and long-lasting impacts on health and development across the lifespan. Much of our work focuses on endocrine disrupting chemicals that interfere with the typical hormone environment during pregnancy, such as phthalates, per- and polyfluoroalkyl substances, and mycoestrogens. Through our ongoing pregnancy cohort studies, we hope to improve our understanding of how these widespread exposures affect our bodies and ultimately, improve maternal and child health.
Understanding Pregnancy Signals and Infant Development is an ongoing prospective birth cohort designed to study maternal prenatal psychological distress and child health. UPSIDE’s key design elements including (1) serial maternal questionnaire and biomarker data across all trimester and (2) pediatric visits at seven time points from birth to 4 years old, allow researchers to examine multiple exposures impacting maternal and child health.
The Infant Development and the Environment Study is a multi-center study designed to examine how everyday chemicals in food, cosmetics, and household products may affect children’s health and development. TIDES researchers are particularly interested in how the mother’s exposure to these chemicals while pregnant may affect children before they are born with changes observable during childhood and later.
The ECHO Program is an extramurally funded program maintained within the Office of the Director at the National Institutes of Health (NIH). The program aims to determine what factors give children the highest probability of achieving the best health outcomes over their lifetimes. ECHO enrolled children from previously establish cohorts and follow them over multiple life stages to understand the etiology of maternal health outcomes such as premature birth, obesity, autism, asthma and behavioral assets that strength resiliency and improve outcomes. Both UPSIDE and TIDES participate in the ECHO program. Our investigators have additional ECHO projects and participate in ECHO writing groups
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