Translational Research Support Core

Translational Research Support

The Translational Research Support Core (TRSC) plays a key role in the research pursued in CEED by supporting the design and implementation of innovative “research that matters” for residents of NJ and beyond. TRSC offers expertise on planning and conducting research across the NIEHS translational research framework.  Informed by basic laboratory research within CEED and concerns of residents , TRSC facilitates research through the design and execution of:

  • population/observational epidemiology,
  • clinical trials and intervention studies, and
  • implementation of meaningful results.

TRSC assists researchers by identifying and addressing obstacles and challenges that impede translation. Thus, TRSC facilitates CEED’s capabilities in dissemination and implementation science and informs implementation strategies to ensure that the novel interventions and evaluations developed by CEED researchers are adopted and used effectively to improve public health.

In 2019, Zarbl and R. Laumbach received support from the NJ ACTS Pilot Grant Program for their studies “Healthy Air and Healthy Eating: Encouraging a Culture of Health in Elizabeth NJ” which helped strengthen CEED’s partnership with residents of   Elizabeth. They piloted the integration of a gardening program with a program to assess and communicate about local air quality and its potential effects on asthma.

Core Directors

Kipen

Howard Kipen, MD, MPH

Co-director
graber

Judith Graber, Ph.D.

Co-director

Core Focus

Close relationships with NJ residents will enhance TRSC’s capacity to accelerate translation of research findings to people who live/work in settings that put them at increased risk of exposure to hazards using evidence-based implementation science approaches. TRSC will ensure rigorous and comprehensive support for research involving human participants.

Clinical Trial Support

Howard Kipen serves as Co-Lead of the NJ ACTS Patient Clinical Interaction Core and N. Fielder oversees the Regulatory Core. The EOHSI clinic is one of five clinical research units within the CTSA highlighting the importance of CEED in NJ-based clinical trials. We leverage this partnership in the newly designed TRSC under Howard Kipen’s direction.

Research

TRSC facilitates research through the design and execution of 1) population/observational epidemiology, 2) clinical trials and intervention studies, and 3) implementation of meaningful results.

Services

TRSC offers an array of services including design of human/population studies; screening, recruitment, and retention of subjects for panel studies, trials, and cohorts; management of protocols and data to ensure regulatory compliance; collection of biospecimens; and data analysis, interpretation, and dissemination of study findings. TRSC also provides field support for study management, survey research, and environmental and biospecimen collection, as well as sample storage within a state-of-the art sample management system. As part of our team of researchers, Andrew Gow is translating his laboratory biomarkers of pulmonary and systemic inflammation into human studies of the mechanism of carbon dioxide induced acute cognitive dysfunction.

TRSC will provide CEED members with access to services designed to facilitate and support hypothesis-driven translational research including, but not limited to:

  • Study design consultation
  • Study coordination and implementation
  • Human Participants Protection
  • Investigator training

Procedures facilitated by the core include:

  • Phlebotomy
  • Continuous ECG recordings
  • Continuous ambulatory blood pressure, central arterial blood pressure and pulse wave analysis
  • Collection of oral material for genotyping
  • Cognitive testing in adults

Translational Research Support Core Pricing

  • Consultation – No charge to Center members
  • Sample Management System Administration
    • First year – $2,800 – included access, annual administrative costs and training for lab manager
    • Annual (year 2 and later) – $1,030
  • All other TRSC services (IRB, study coordination, screening, subject interaction, etc.) are billed at an hourly rate of $67/hour. Please ask for a consultation to receive a quote.

TRSC works closely with the EOHSI Environmental and Occupational Health Clinical Center (EOHCC) which provides health services to employees within Rutgers Health . Consultation regarding planning of research and support of grant applications is provided at no cost to CEED members or those using our services, including writing pilot project grant applications. Staff time, including nursing and phlebotomy services, data entry, cleaning, and analysis, as well as cost of supplies more than that provided in the TRSC budget, are charged back to CEED investigators at cost. Costs are also recovered by inclusion of TRSC staff salaries on extramural grant budgets. 

Since the initiation of the NJ Alliance for Clinical and Translational Science (NJ ACTS), members of CEED have leveraged their long-standing expertise in translational research to advance the goals of the CTSA Hub. TRSC, with the Rutgers Environmental and Occupational Health  Clinical Center, is one of five Clinical Research Centers of NJ ACTS. Through this partnership, TRSC has been able to extend the reach of its services by increasing access to cohorts, as well as informatics tools that enable broader recruitment of participants into recent studies.

TRSC by the Numbers

Cllinical Translational Studies
53
IRB Submissions/Modifications
441
Study Participants
2283
Study Visits
3453
Principal Investigators
26
Clinical Trials Registered at clinicaltrials.gov
4
Publications Supported
62
Staff Authored Publications
20

Recent Core Publications

Pavuk M, Adgate JL, Bartell SM, Bell E, Brown LM, Laumbach RJ, Schaider LA, van T’ Erve TJ, Bailey JM, Botelho JC, Calafat AM, Cutler CR, Forand S, Graber JM, James-Todd T, Jeddy Z, Kato K, Mowry N, Nair AS, Ohman-Strickland P, Rago P, Schaefer AM, Starling AP, Vieira VM, Weems MM, Wiant KF, Bove FJ. Multi-site study of communities with PFAS-contaminated drinking water: Methods, demographics, and PFAS serum concentrations. Environ Int. 2025 Jun 12;202:109589. doi: 10.1016/j.envint.2025.109589. Epub ahead of print. PMID: 40570576.

Ayappa I, Laumbach R, Black K, Weintraub M, Agarwala P, Twumasi A, Sanders H, Udasin I, Harrison D, de la Hoz RE, Chen Y, Chitkara N, Mullins AE, Castillo HR, Rapoport DM, Lu SE, Sunderram J. Nasal resistance and inflammation: mechanisms for obstructive sleep apnea from chronic rhinosinusitis. J Clin Sleep Med. 2024 Oct 1;20(10):1627-1636. doi: 10.5664/jcsm.11216. PMID: 38888597; PMCID: PMC11446130.

Graber JM, Shah NN, Berezniak JG, Black TM, Black K, Lu SE, Laumbach RJ, Edwards DL, Koeppel MDH, Jahnke SA, Austin E, Steinberg MB, Calkins MM, Caban-Martinez AJ, Hinton K, Lubina KA, Metlitz SP, Grant C, Osgood RF, Gulotta J, Kubiel BS, Burgess JL. Cancer-Related Behavioral Risk Factors Among Volunteer and Career Firefighters Enrolled in the Cancer Assessment and Prevention Study (CAPS) and the Fire Fighter Cancer Cohort Study (FFCCS). Int Fire Serv J Leadersh Manag. 2024;18:22-36. PMID: 40162371; PMCID: PMC11951304.

Lu FT, Gupta D, Fiedler N, Satish U, Black KG, Legard A, De Resende A, Guo C, Gow AJ, Kipen HM. Mechanisms Underlying Acute Cognitive Impairment following Carbon Dioxide Inhalation in a Randomized Crossover Trial. Environ Health Perspect. 2024 Oct;132(10):107702. doi: 10.1289/EHP14806. Epub 2024 Oct 28. PMID: 39466336; PMCID: PMC11515854.

Myers NT, Laumbach RJ, Black KG, Ohman-Strickland P, Alimokhtari S, Legard A, De Resende A, Calderón L, Lu FT, Mainelis G, Kipen HM. Portable air cleaners and residential exposure to SARS-CoV-2 aerosols: A real-world study. Indoor Air. 2022 Apr;32(4):e13029. doi: 10.1111/ina.13029. PMID: 35481935; PMCID: PMC9111720.

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